Integrated Granulation Line
The Force Multiplier® - Integrated Pharmaceutical Wet Granulation Suite
The Force Multiplier® is Gansons complete integrated wet granulation line, combining a High Shear Mixer Granulator, inline wet mill, Fluidised Bed Dryer, inline dry mill, and IBC Lift Blender under a single centralised automation platform. It eliminates manual inter-equipment transfers, reduces operator touchpoints, and delivers predictable, reproducible batch outcomes at up to 18 tonnes per day. The Force Multiplier® is the preferred wet granulation solution for the world’s fastest-growing regulated generic pharmaceutical manufacturers.
High Shear Mixer Granulator (HSMG)
The core wet granulation unit. Iwata™ impeller and chopper design, dead-spot-free bowl geometry, electromechanical endpoint detection, 12 Bar shock pressure resistance, ATEX rated configurations. See the HSMG product page for full technical detail.
Inline wet mill
De-lumps wet granulate mass immediately on discharge from the HSMG before it enters the dryer. Lumps transferred directly to a FBD dry only on the surface, leaving wet centres that cause inconsistent moisture content and extended drying times.
Fluidised Bed Dryer with Cyklon®
Gansons proprietary Cyklon® air distributor reduces drying time by up to 70% versus standard FBDs. Granules are dried uniformly and gently. See the FBD product page for full technical detail.
Lifting device with
Dry mill
A hydraulic lifting device raises the dried product container from the FBD and docks it to the inline dry mill for post-drying particle sizing, removing a manual transfer step. The dry mill delivers the target particle size distribution in a single automated step, ready for compression. Compatible with material handling system (MHS) and sifting operations.
IBC Bin Blender
Lubricant addition and final blend are performed inside the IBC without material transfer. The blend is transferred directly to the tablet press, completing the granulation-to-compression sequence without a single open powder transfer.
Increased efficiency
- Compact Footprint: The design allows for a space-efficient setup without compromising on throughput
- Line-Balanced Configuration: Optimized for maximum throughput, ensuring that each component operates efficiently within the overall system
- WIP system for in-situ cleaning (can be recipe driven)
- Predictable scalability from R&D to production
Increased Output with improved safety
- Closed transfer of materials ensures minimal operator exposure
- Safety interlocks
- 12-Bar shock-resistant designs available for structural integrity and containment
- ATEX rated (flame proof) designs based on zoning requirement as per customer configuration.
Increased Output with improved safety
- Closed transfer of materials ensures minimal operator exposure
- Safety interlocks
- 12-Bar shock-resistant designs available for structural integrity and containment
- ATEX rated (flame proof) designs based on zoning requirements. All components are by default compliant to a Zone 2/22 production environment
Automation and Control
Gansons equipment is available with an integrated intelligent automation platform. Key features include:
- PLC/SCADA-based control with touch-screen HMI
- Centralised recipe management with role-based access control
- IoT enabled for remote monitoring and pre-emptive analytics
- Integrable with any site architecture including MES, ERP, and LIMS
- Customised reporting and smart graphs for lot reproducibility
- Industry-leading IPC processors for fast, reliable control performance
- 21 CFR Part 11 compliant automation available as an add-on for regulated pharmaceutical facilities
- GAMP 5-aligned computerised system validation documentation supplied with 21 CFR Part 11 configurations
Installed in facilities regulated by US-FDA, UK-MHRA, EMA, WHO-GMP, Japan-PMDA, TGA, SAHPRA, MCC, and health authorities in 40+ countries. CE, UL, ATEX, ISO, and IEC configurations available on request.
Compliance and Certifications
Frequently asked questions
What does the Force Multiplier® include?
Why is an inline wet mill important in a granulation suite?
Lumps from the HSMG dry only on the surface in the FBD, leaving wet centres. The inline wet mill de-lumps the granulate mass immediately on HSMG discharge, ensuring uniform particle size, consistent drying, and better granule structure for compression.
What throughput can the Force Multiplier® achieve?
Up to 20 tonnes per day in high-capacity configurations. Individual line sizing is customised to customer throughput requirements, regulatory environment, and facility footprint.
Is the Force Multiplier® suitable for HPAPI manufacturing?
Yes. Closed material transfer throughout the line eliminates open powder handling. ATEX rated and 12 Bar configurations are available as per customers request. Gansons process technology team provides OEB-specific containment assessments for HPAPI granulation projects.
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